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45
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[Original]
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Microdialysis Study of Drug Effects on Central Nervous System - Changes of Dopamine Levels in Mice Striatum after Oral Administration of Methylenedioxypyrovalerone -
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Tatsu FUWA, Nobutaka FUKUMORI, Toyohito TANAKA, Yoshikazu KUBO, Akio OGATA, Shin-ichi UEHARA, Yoshiko HONDA, Tohru KODAMA
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Extracellular levels of dopamine (DA) and serotonin (5-HT) were determined in the striatum of freely-moving mice, using microdialysis and high performance liquid chromatography with electrochemical detection (HPLC-EC). Dialysates were collected at 10 minute intervals for 2.5 hours after oral administration of methylenedioxypyrovalerone (MDPV). Sixty minutes after MDPV administration, the experimental group showed increased extracellular DA levels about 2.1 times higher than those of the control group. MDPV had a milder effect on the increase of DA levels than the amphetamine-like stimulants, methamphetamine (METH) and methylenedioxymethamphetamine (MDMA). However, MDPV showed no significant influence on 5-HT.
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microdialysis, methylenedioxypyrovalerone, dopamine, striatum
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| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
287-292,
2007 |
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46
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[Original]
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Screening Test to Nervous System of Male Mice Administrated Extract from Commercial Harmala
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Nobutaka FUKUMORI, Hiroshi ANDO, Yoshikazu KUBO, Katsuhiro YUZAWA, Akemichi NAGASAWA, Hiroshi TAKAHASH, Norio YANO, Tatsu FUWA, Akio OGATA and Shinichi UEHARA
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screening test, nervous system, male mice, harmala extract
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| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
293-297,
2007 |
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47
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[Original]
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Micronucleus Test of Attapulgite and Wollastonite in Chinese Hamster Lung V79-4 Cells
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Hiroshi FUJITA, Akio OGATA and Shin-ichi UEHARA
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asbestos, asbestos substitutes, Atgel, NYGLOS, NYAD
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| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
299-301,
2007 |
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48
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[Original]
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Considerations on Hepatic Fatty Changes in Control ICR Mice
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Yukie TADA, Norio YANO, Hiroshi TAKAHASHI, Katsuhiro YUZAWA, Hiroshi ANDO, Yoshikazu KUBO, Akemichi NAGASAWA, Akio OGATA, Dai NAKAE and Shin-ichi UEHARA
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ICR mice, liver, fatty changes, body weight, feed efficiency, total-cholesterol, triglyceride
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| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
303-309,
2007 |
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49
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[Original]
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Teratological and Reproductive Study of a House-dust Remover Given Newborns in ICR Mice
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Tomoko FUJITANI, Akio OGATA, Yoshikazu KUBO, Hiroshi ANDO, Hiroshi TAKAHASHI, Norio YANO, Katsuhiro YUZAWA, Akemichi NAGASAWA, Ikue SAITO, Hisashi KAMIMURA, Dai NAKAE and Shin-ichi UEHARA
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Effect of a widely used house-dust remover, Product A: spray-type, given orally during postnatal 21 days was evaluated in teratological and reproductive study. Newborn pups of ICR mouse were given 0 (control) to 2.0 mL of Product A/kg body weight/day by gavage from postnatal day 0 to 20. After weaning at 21 days old, they were housed individually and, at 10 weeks old, mated one male to one female in the each dose groups for 3 days. Females with vaginal plug were divided into the teratogenicity study and the reproductive study. There was no difference between the control and the dosed groups on number of mated and gestated females. In the teratogenicity study, there was no difference on number of corpora lutea, implantation, resorption (early and late), or live fetus, mean weight of male or female fetus, sex ratio of fetus and external or skeletal malformation. Also, in the reproductive study, there was no difference on litter size, litter weight, number of live or dead offsprings, sex ratio of offsprings, mean weight of offspring. However, number of female F1 died up to postnatal day 21 in the 2.0 mL /kg b.w. group was significantly higher than that of the control group and relative testis weight of male F1 at postnatal day 21 in the 2.0 mL/kg b.w. group was significantly lower than that of the control group.
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house-dust remover, mouse, newborn, teratogenicity, reproductive toxicity
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| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
311-316,
2007 |
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50
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[Original]
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Safety Evaluation of a House-dust Remover in Newborn and Adult Mice 2)
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Tomoko FUJITANI, Akio OGATA, Hiroshi TAKAHASHI, Norio YANO, Yoshikazu KUBO, Hiroshi ANDO, Katsuhiro YUZAWA, Akemichi NAGASAWA, Ikue SAITO, Hisashi KAMIMURA, Dai NAKAE and Shin-ichi UEHARA
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Sub-acute effect of a widely used house-dust remover, Product B: spray-type, was evaluated in newborn or adult ICR mice. From postnatal day 0 to 20, newborn pups were given 0 (control) to 4.0 mL of Product B/kg body weight/day by gavage. Body weight during the administration period, main organ weight and hematology at the end of experiment were examined. Increased mortality, decreased body weight gain and decreased organ (liver, thymus adrenal grand and testis) weight, were observed in male and female pups given Product B above 2.0 mL/kg body weight/day. Adult male and females (11 weeks old), given up to 4.0 mL of Product B/kg body weight/day by gavage for 21 consecutive days, were not affected in those parameters.
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house-dust remover, toxicity, mouse, newborn, adult
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| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
317-321,
2007 |
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51
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[Original]
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Safety Evaluation of a House-dust Remover in Newborn and Adult Mice 3)
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Tomoko FUJITANI, Akio OGATA, Hiroshi TAKAHASHI, Norio YANO, Yoshikazu KUBO, Hiroshi ANDO, Katsuhiro YUZAWA, Akemichi NAGASAWA, Ikue SAITO, Hisashi KAMIMURA, Dai NAKAE and Shin-ichi UEHARA
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Sub-acute effect of a widely used house-dust remover, Product C: spray-type, was evaluated in newborn or adult ICR mice. From postnatal day 0 to 20, newborn pups were given 0 (control), 1.0, 2.0 or 4.0 mL Product C /kg body weight /day by gavage. Adult male and females (12 weeks old) were given 0 (control), 2.0, 4.0 8.0 mL Product C /kg body weight /day by gavage for consecutive 21 days. Body weight during administration period, main organ weight and hematology at the end of experiment were examined. There was no effect on those parameters examined in newborn or adult mice. As product C contains 17.6% ethanol, 18% ethanol solution was also examined at dose revel of 4.0 mL/kg b.w./day in newborn pups and there was no adverse effect on those parameters examined.
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house-dust remover, toxicity, mouse, newborn, adult
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| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
323-327,
2007 |