|
10
|
[Original]
|
Newly Detected Compounds in Uncontrolled Drugs Purchased in Tokyo between April 2006 and March 2007
|
|
|
Misako TAKAHASHI, Jin SUZUKI, Machiko NAGASHIMA, Takako SETO and Ichiro YASUDA
|
|
An analysis of 99 uncontrolled drugs purchased in Tokyo between April 2006 and March 2007 detected 9 new designer drugs. The detected compounds were as follows: 2-phenylethanamine, 2-(2,4,5-trichloro-3,6-dimethoxy phenyl)ethanamine, 2-[4-(2-aminoethyl)-2,5-dimethoxyphenylthio]ethanol, 2-(ethylamino)-1-phenyl-propan-1-one, 1-(4-chloro-2,5-dimethoxyphenyl)propan-2-amine, N-[1-(benzo [d][1,3]dioxol-5-yl)propan-2-yl]-N-methylhydroxylamine, 1-(benzo[d][1,3]dioxol -5-yl)-2-(pyrrolidin-1-yl)pentan-1-one, 2-amino-3-(5-hydroxyindolin-3-yl)propanoic acid, and 2-methylbutyl nitrite. The structure of each compound was identified by a combination of NMR, UV and MS analyses. This paper describes the data from the analysis of these 9 compounds.
|
|
Uncontrolled Drugs, N-hydroxy-N-methyl-3,4-methylenedioxyamphetamine, 1-benzol[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one, 4-chloro-2,5-dimethoxy-amphetamine,2-[4-(2-aminoethyl)-2,5-dimethoxyphenylthio]ethanol, 2-Methylbutyl nitrite, 2,5-dimethoxy-3,4,6-trichlorophenethylamine, NMR, MS
|
| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
83-87,
2007 |
|
|
11
|
[Original]
|
Spectrum Data of 4th Governor-designated Drugs and the Analyses of Illegal Drugs Purchased Apr. 2006-Mar. 2007
|
|
|
Machiko NAGASHIMA, Takako SETO, Misako TAKAHASHI, Jin SUZUKI and Ichirou YASUDA
|
|
governor-designated drugs, 1-(4-methoxyphenyl)-N-methylpropan-2-amine, 2-methylamino-1-(3,4-methylenedioxyphenyl)-propan-1-one, illegal drugs, marketing research of illegal drugs
|
| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
89-92,
2007 |
|
|
12
|
[Original]
|
Identification of Rhubarb in the Dietary Supplement Caused Health Damage
|
|
|
Yukiko SUZUKI, Tatsuo FUKUDA, Masao YOSHIZAWA, Masako ARAGANE, Shigemi KITAGAWA, Junichi NAKAJIMA, Hiroko SHIODA, Tomoko HAMANO and Ichiro YASUDA
|
|
dietary supplement, weight loss capsule "tentenso", rhubarb, speculum, TLC
|
| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
93-95,
2007 |
|
|
13
|
[Original]
|
Analysis of UV Absorbents in Quasi-drugs and Cosmetics
Simultaneous Determination of 14 UV Absorbents Including Ferulic Acid and Drometrizole Trisiloxane
|
|
|
Michiko MIYAMOTO, Ken'ichiro MORI, Yoshiaki NAKAMURA, Kiyoshi TERAJIMA, Nahomi OHNUKI, Toshiro YOKOYAMA, Shuzo OGINO and Kazuo SAITO
|
|
A method for simultaneous determination of 14 UV absorbents including ferulic acid and drometrizole trisiloxane in quasi drugs and cosmetics was developed. The chemical names and abbreviations of the 14 UV absorbents are as follows: ferulic acid (HMC), tetrahydroxybenzophenone (THB), ethyl p-aminobenzoate (EAB), dihydroxybenzophenone (DHB), dihydroxydimethoxybenzophenone (DHDMB), 2-hydroxy-4-methoxybenzo-phenone (HMB), 2-ethylhexyl(Z)-4-(3,4-dimethoxybenzylidene)-2,5-dioxo-1-imidazolyzine propionate (EBP), 4-tert-butyl-4'-methoxydibenzoylmethane (BMB), 2-ethylhexyl p-methoxy-cinnamate (EMC), 2-ethylhexyl salicylate (ESA), 2-ethylhexyl 2-cyano-3,3-diphenylacrylate (ECA, octocrylene), drometrizole trisiloxane (BPS), 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)-anilino]-1,3,5-triazine (TEAT, octyltriazone), 2,2'-methylene-bis-[6-(2H-benzo-triazole-2-yl)-4-(1,1,3,3-tetramethylbutyl)-phenol] (MBP). A 0.4 g sample of quasi drugs and cosmetics was mixed with 4 mL of tetrahydrofuran, and 6 mL of acetonitrile was added to this mixture with supersonic treatment for sufficient dissolution. The total volume was set at 20 mL by adding acetonitrile further. The solution was then filtered through a 0.45 µm membrane filter and injected into the HPLC system. Analytical condition of HPLC were as follows, columm: ZORBAX SB-C8 (4.6 mm i.d.×150 mm), 40°C, mobile phase: gradient, aceto-nitrile, water (0.2% formic acid) (40:60) to (100:0), 0.5 mL/min, injection volume 2 µL, detector UV 310 nm. This method, which was not influenced by foreign substances, enabled precise analysis of the 14 absorbents.
|
|
UV absorbents, quasi-drugs, cosmetics, simultaneous determination
|
| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
97-101,
2007 |
|
|
14
|
[Original]
|
Examination of Antiseptics in Cosmetics (April 2004 - March 2006) and Improvements in the Analytical Method
|
|
|
Ken'ichiro MORI, Yoshiaki NAKAMURA, Nahomi OHNUKI, Kiyoshi TERAJIMA, Michiko MIYAMOTO, Shuzo OGINO and Kazuo SAITO
|
|
Analysis data of antiseptics in 651 cosmetics, obtained in our laboratory between April 2004 and March 2006, were classified and aggregated. The following 24 compounds were studied as cosmetic antiseptics : methylparaben (MP), ethylparaben (EP), propylparaben (PP), isopropylparaben (IP), butylparaben (BP), isobutylparaben (IB), phenoxyethanol (PE), dehydroacetic acid and its salts (DA), sorbic acid and its salts (SO), benzoic acid and its salts (BA), salicylic acid and its salts (SA), isopropylmethylphenol (IM), 3-(4-chlorophenoxy)propane-1,2-diol (CP), methylchloroisothiazolinone/methylisothiazolinone (KS), chlorohexidine (CH), hinokitiol (HO), photosensitizer 201 (P2), p-chlorometaxylenol (CX), triclosan (TC), benzyl alcohol (BO), benzalkonium chloride (BK), benzethonium chloride (BZ), methylchloroisothiazolinone (MT) and formaldehyde (F). Among these antiseptics, MP was used most frequently, followed by PE and then PP. Based on these results, improvements were made to the routine screening method for cosmetic antiseptics: 10% water was added to the HPLC mobile phase of the official method, preparing two standard solutions, one for the eleven compounds MP, PE, EP, PP, IP, BP, IB, DA, SO, BA and SA and the other for the two compounds, CP and IM. This method enabled sufficient separation of MP and PE and rational analysis of the thirteen antiseptics.
|
|
cosmetics, antiseptics, parabene, phenoxyethanol, HPLC
|
| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
103-106,
2007 |
|
|
15
|
[Original]
|
Formaldehyde Contained in Transferable Picture Tattoo Seals and Face Painting Tools
|
|
|
Nahomi OHNUKI, Yoshiaki NAKAMURA, Kiyoshi TERAJIMA, Ken'ichiro MORI, Michiko Miyamoto, Shuzo OGINO, and Kazuo SAITO
|
|
Transferable picture tattoo seals and face painting pens and crayons were analyzed by HPLC for the presence of formaldehyde. Incubated in artificial perspiration for 2 hours at 40°C, all seals showed elution of formaldehyde. Meanwhile, incubated in water instead of artificial perspiration, some seals did not show elution of formaldehyde. Formaldehyde elution increased with time. For face painting tools, fluorescent crayons showed formaldehyde, but other crayons and pens did not show the substance.
|
|
transferable picture tattoo seal, face/body painting, formaldehyde
|
| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
107-110,
2007 |
|
|
16
|
[Information]
|
Stability and Drug Consultation on Comminuted Warfarin Potassium Tablets
|
|
|
Keiko MINOWA, Kiyoko KISHIMOTO, Takako MORIYASU, Hideo KADOI and Ichiro YASUDA
|
|
comminuted warfarin potassium tablets, hospital preparation medicine, stability, long term testing, light irradiation, shield the light, optical isomer, drug consultation
|
| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
111-115,
2007 |
|
|
17
|
[Information]
|
Determination of Heavy Metals and Arsenic in Crude Drugs
|
|
|
Hiroko SHIODA, Tomoko HAMANO, Junichi NAKAJIMA and Ichiro YASUDA
|
|
Crude drugs, increasingly used in a number of countries as alternative remedies, have raised worldwide concerns about their quality and safety. Accordingly, the Japanese Pharmacopoeia is currently establishing standards for heavy metal and arsenic impurities in crude drugs. However, its limit tests do not reveal the content of each metal and therefore are not sufficient for ensuring the safety of crude drugs. The precise content of each metal is required. Therefore, using an atomic absorption spectrometer and other measures, 51 samples of 10 crude drugs were examined for the contents of mercury, arsenic, lead, cadmium, copper and chromium. In comparison with foods, the samples showed the same levels of mercury and copper and slightly higher levels for the other four metals.
|
|
heavy metal, arsenic, crude drug, mercury, lead, cadmium, copper, chromium
|
| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
117-122,
2007 |
|
|
18
|
[Information]
|
Determination of Organochlorine and Pyrethroid Pesticides in Preparations of Crud Drug Extract
|
|
|
Hiroko SHIODA, Tomoko HAMANO, Junichi NAKAJIMA and Ichiro YASUDA
|
|
preparations of crud drug extract, organochlorine pesticide, pyrethroid pesticide, Total BHC, Total DDT
|
| Ann.Rep.Tokyo Metr.Inst.P.H., 58,
123-125,
2007 |