58 The Effect of Two Weeks Administration of Tetrabromobisphenol A, a Flame Retardant, in ICR Mice
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| Yukie TADA, Tomoko FUJITANI, Akio OGATA and Hisashi KAMIMURA |
| tetrabromobisphenol A, flame retardant, mouse, liver, lipid metabolism, total-cholesterol |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,351-355,2006 |
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| 59 Immature Uterotrophic Assay of Tetrabromobisphenol A, a Flame Retardant, in ICR Mice
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| Yukie TADA, Norio YANO, Hiroshi TAKAHASHI, Katsuhiro YUZAWA, Hiroshi ANDO, Yoshikazu KUBO, Akemichi NAGASAWA, Akio OGATA and Hisashi KAMIMURA |
| tetrabromobisphenol A, flame retardant, uterotrophic assay, immature rodent, mouse |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,357-360,2006 |
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| 60 Placental Transfer of Tetrabromobisphenol A and Excretion to Milk in Mice
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| Tomoko FUJITANI, Yukie TADA, Hiroshi TAKAHASHI, Norio YANO, Hiroshi ANDO, Yoshikazu KUBO, Katsuhiro YUZAWA, Akemichi NAGASAWA, Akio OGATA and Hisashi KAMIMURA |
| Tetrabromobisphenol A, a brominated flame-retardant, has been widely detected in the environment, wildlife, and also in human plasma, suggesting direct exposure or through the food-chain. Distribution of TBBPA, after oral administration, was investigated in pregnant (on day 10 or 16 of gestation) and lactating (on postnatal day 10) mice. At 1 or 3 hours after dosing, TBBPA was distributed in the blood, liver, kidney, and brain of the dam, in the embryo, conceptus, and amniotic fluid (on day 10 of gestation), in the fetus, placenta, amnion, and amniotic fluid (on day 16 of gestation), and in the contents of stomach, liver, and kidney of suckling pups (on postnatal day 10). TBBPA levels in the maternal liver, kidney, conceptus, fetus, amnion, and contents of stomach in suckling pups were higher than that in maternal blood, at 1, 3, 6, and/or 12 hours after dosing. Especially in the maternal liver, a large amount of TBBPA was detected. At 24 hours after dosing, TBBPA levels in those tissues or body fluids were almost declined. However, the level in liver at 24 hours after dosing was yet higher than the peak level in blood of dams on day 10 or 16 of gestation. The results indicated the necessity to examine the effects of TBBPA in the maternal liver, embryo, fetus, and suckling pups. |
| tetrabromobisphenol A, distribution, placental transfer, excretion to milk, mouse, brominated flame-retardant |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,361-365,2006 |
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| 61 Distribution of Tetrabromobisphenol A and its Conjugates in Mice
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| Tomoko FUJITANI, Yukie TADA, Hiroshi TAKAHASHI, Norio YANO, Hiroshi ANDO, Katsuhiro YUZAWA, Akemichi NAGASAWA, Akio OGATA and Hisashi KAMIMURA |
| Tetrabromobisphenol A (TBBPA), a brominated flame-retardant, has been widely detected in the environment and its placental transfer and excretion to milk was observed in mice after single oral administration. Distribution of TBBPA and its conjugates (glucuronide and/or sulfate) was investigated in pregnant (on day 10 or 16 of gestation) and lactating (on postnatal day 10) mice given dietary TBBPA (100, 1,000 or 10,000 ppm) from day 0 of gestation. Free-TBBPA was detected in the blood, liver and kidney of dams, in the embryo, conceptus and amniotic fluid (on day 10 of gestation), in the fetus, placenta, amnion and amniotic fluid (on day 16 of gestation), and in the contents of stomach in suckling pups, mainly in the 10,000 ppm group. TBBPA levels in the maternal liver and contents of stomach in suckling pups were higher than that of maternal blood and TBBPA was detected in the liver of dam and contents of stomach in suckling pups in the group of lowest TBBPA in the diet. Although free-TBBPA was not detected in the liver and kidney of suckling pups, conjugated TBBPA was detected in those organs. Total TBBPA level in the maternal liver was markedly high to compare with in other organs or blood. |
| tetrabromobisphenol A, distribution, placental transfer, excretion to milk, mouse, brominated flame-retardant |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,367-370,2006 |
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| 62 Biological Effects on Mice Administrated Dietary Supplement "Tentenso" Suffered Health Damage
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| Nobutaka FUKUMORI, Hiroshi ANDO, Yoshikazu KUBO, Katsuhiro YUZAWA, Akemichi NAGASAWA, Hiroshi TAKAHASHI, Norio YANO, Seiji YOSHIDA, Yukie TADA, Akio OGATA and Hisashi KAMIMURA |
| dietary supplement, capsule "tentenso", health damage, biological effects, mouse |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,371-376,2006 |
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| 63 Mutagenicity of "Tentenso"
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| Seiji YOSHIDA, Hiroshi FUJITA, Akio OGATA and Hisashi KAMIMURA |
| dietary supplements, "tentenso", sibutramine, phenolphthalein, Ames test, chromosome analysis, chinese hamster |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,377-380,2006 |
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| 64 Effects of N-Nitrosofenfluramine, a Component of Chinese Dietary Supplement for Weight Loss, on Monoamines Neurotransmission
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| Kanako SATOH, Ryouichi NONAKA, Fumiko NAGAI, Akio OGATA, Hisashi KAMIMURA and Tsuyoshi SATOH |
| Many cases of hepatopathy, including deaths, have frequently occurred after ingestion of Chinese dietary supplements for weight loss containing N-nitrosofenfluramine (N-fen), a nitroso derivative of fenfluramine (Fen), which is used for the treatment of obesity in the USA. Since Fen decreases appetite by decreasing the serotonin level and exhibits an antibiotic effect, N-fen may have been added, expecting a similar effect. Thus, we synthesized N-fen, and investigated its effect on the cerebral serotonin nervous system to investigate whether N-fen exhibits an anorectic effect. Effects of reuptake and release of monoamine neurotransmitters (dopamine (DA), serotonin (5HT), and norepinephrine (NE)) were investigated. N-fen slightly inhibited 5HT reuptake, and did not inhibit the reuptakes of DA and NE. Moreover, N-fen did not affect the release of the 3 monoamines. These findings suggested that N-fen did not have a serotonin nerve fiber-mediated anorectic effect. |
| N-nitrosofenfluramine, fenfluramine, serotonin, dopamine, norepinephrine, hepatopathy, central nervous system, Chinese diet supplement |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,381-386,2006 |
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| 65 Safety Evaluation of a House-dust Remover in Newborn and Adult Mice
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| Tomoko FUJITANI, Yukie TADA, Hiroshi TAKAHASHI, Norio YANO, Hiroshi ANDO, Katsuhiro YUZAWA, Akemichi NAGASAWA, Akio OGATA and Hisashi KAMIMURA |
| Toxicity of a widely used house-dust remover, Product A: spray-type, was evaluated in newborn or adult ICR mice. From postnatal day 0 to 20, newborn pups were given 0 (control) to 4.0 mL of Product A/kg body weight/day by gavage. Mortality, body weight during the administration period, and main organ weight, hematology or plasma clinical chemistry at the end of the experiment were examined. In male and female pups given Product A above 2.0 mL/kg body weight/day, increased mortality, decreased body weight gain, decreased organ (liver, spleen and testis) weight, and increased plasma cholesterol concentration were observed. Adult males and females (11 to 13 weeks old), given up to 4.0 mL Product A/kg body weight/day by gavage for 21 consecutive days, were not affected in those parameters. |
| house-dust remover, toxicity, mouse, newborn |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,387-392,2006 |