11 Quality Control for Hospital Preparation of Medicine - The Stability Test -
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| Kiyoko KISHIMOTO, Machiko NAGASHIMA, Sutemi SHIGEOKA, Keiko MINOWA, Hideo KADOI, Takako MORIYASU, Takako SETO and Ichiro YASUDA |
| ointment, liquid, stability, long term testing, accelerated, testing, stress testing, expiry date, betamethasone valerate, ascorbic acid ester, povidone-iodine, adrenaline, HPLC |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,93-99,2006 |
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| 12 Quality Control for Hospital Preparation of Medicine – Powder Preparations –
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| Kiyoko KISHIMOTO, Keiko MINOWA, Sutemi SHIGEOKA, Hideo KADOI, Takako MORIYASU, Misako TAKAHASHI, Machiko NAGASHIMA and Ichiro YASUDA |
| hospital preparation of medicine, powder preparation, content uniformity, quality control, HPLC |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,101-103,2006 |
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| 13 Analysis of Non-Metabolism Uncontrolled Drugs in Human Urine using GC-MS
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| Misako TAKAHASHI, Jin SUZUKI, Machiko NAGASHIMA, Takako SETO and Ichiro YASUDA |
| In recent years, a number of newer designer drugs have appeared on the uncontrolled drug market. We analyzed nonmetabolism drugs in the urine of a poisoning patient from drug abuse. We established an analysis method using GC-MS for the screening and identification of four phenethylamines, four tryptamines and 1-(3-chlorophenyl)-piperazine. We also identified examples, which were detected in urine, using a reported method, including 1-(3-chlorophenyl)piperazine, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-N-methylpropan-2-amine and N-(2-propyl)-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)propan-2-amine. |
| uncontrolled drug, urine, non-metabolism drug, governordesignated drug, GC/MS, N-(2-propyl)-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)propan-2-amine, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-N-methylpropan-2-amine, 1-(3-chlorophenyl)piperazine |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,105-108,2006 |
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| 14 Spectrum Data of the 3rd Governor-designated Drugs and the Analyses of Uncontrolled Drugs Purchased Apr. 2005 - Mar. 2006
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| Machiko NAGASHIMA, Takako SETO, Misako TAKAHASHI, Jin SUZUKI and Ichiro YASUDA |
| uncontrolled drugs, governor-designated drugs, 3-(2-aminopropyl)-5-methoxyindole, 2,4,5-trimethoxyamphetamine, 2,5-dimethoxy-4-ethyltiophenethylamine, 4-methoxyphenyl-N-methyl-2-propanamine, 4-fluoro-N-methylamphetamine, 1-piperonylpiperazine, 2-methoxy-4,5-methylenedioxyamphetamine |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,109-113,2006 |
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| 15 Qualitative Method of Nitrite Inhalants
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| Jin SUZUKI, Misako TAKAHASHI, Takako SETO, Machiko NAGASHIMA, Chiyomi OKUMOTO and Ichiro YASUDA |
| A qualitative method of nitrite inhalants using NMR was established. After nitrite inhalants had been diluted with the solvent, they were measured with NMR. The included nitrous acid ester was identified and confirmed from spectrum data. Moreover, a nitrous acid ester without commercial items was synthesized, and identified and confirmed from NMR and GC/MS data. iso-Propyl nitrite, iso-butyl nitrite, n-amyl nitrite, iso-amyl nitrite and 2-methylbutyl nitrite ester were identified from products on the market. |
| nitrite inhalant, n-amyl nitrite, iso-amyl nitrite, iso-propyl nitrite, iso-butyl nitrite, cyclohexyl nitrite, NMR, GC/MS |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,115-120,2006 |
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| 16 Analysis of Psychotropic Components in Commercial Botanical Drugs
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| Tomoko HAMANO, Hiroko SHIODA, Junichi NAKAJIMA and Ichiro YASUDA |
| An effective screening method with a small sample for the detection of botanical and chemical psychotropic components in commercial botanical drugs was established. Alkaloids were extracted by strong acid and treated with a small volume pre-column. Salvinorin A (Sal.A), its non-alkaloid, was extracted immediately from the residue treated with strong acid. Alkaloids and Sal.A in each of the treated samples were successfully detected by TLC, LC/PDA, LC/MS and/or GC/MS. As a result of the analysis of commercial botanical drugs, it was revealed that the products mixed with the psychotropic components, not only botanical but also chemical, were distributed actually. |
| commercial botanical drugs, psychotropic components, TLC, LC/PDA, LC/MS, GC/MS, screening method, identification |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,121-126,2006 |
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| 17 Diagnosis of Cannabis sativa by Figure and Chemical Analysis
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| Masao YOSHIZAWA, Masako ARAGANE, Tatsuo FUKUDA, Yukiko SUZUKI Shigemi KITAGAWA, Hiroko SHIODA and Ichiro YASUDA |
| Cannabis sativa, TLC, Diagnosis, THC, Cannabis Seeds |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,127-132,2006 |
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| 18 Determination of Denatonium Benzoate in Cosmetics and their Antifeeding Property
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| Ken'ichiro MORI, Yoshiaki NAKAMURA, Nahomi OHNUKI, Kiyoshi TERAJIMA, Toshiro YOKOYAMA, Michiko MIYAMOTO, Shuzo OGINO and Kazuo SAITO |
| A method for the determination of denatonium benzoate, benzyldiethyl-N-2,6-xylylcarbamoylmethyl-ammonium benzoate, abbreviated to DB, in cosmetics was developed. A cosmetic sample of 1-2 g was weighed and dissolved with methanol up to a volume of 10 mL. When a precipitate was seen, it was cleared using a high speed centrifuge. The solution was loaded on a cation exchange column, washed with methanol, and eluted by 1%HCl-MeOH 10 mL. The eluate was evaporated to dryness, dissolved by 0.1 %HCl-MeOH 500 µL, and injected on an HPLC. The conditions for HPLC were as follows: column: ODS, mobile phase: water ·acetonitrile (3:7), containing 0.01 mol/L sodium 1-pentanesulfonate, 0.015 mol/L sodium sulfate, injection volume: 20 µL, detector: 206 nm. The detection limit was 0.1 ppm. By this method, 1.0 to 9,000 ppm of DB were detected in five imported cosmetics without any interference. A 1.0 mL of 1.0 ppm DB water solution fully convinced us of DB's antifeeding property because of the intense bitter taste. We have rarely seen Japanese cosmetics or household articles containing DB as aversive agents to prevent accidental ingestion, but there are many and wide ranges in US or European articles. |
| cosmetics, denatonium benzoate, aversive agents to prevent accidental ingestion, antifeeding property, repellents, HPLC |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,133-136,2006 |
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| 19 Investigation of Colorants and Metals Contained in Transferable Picture Tattoos and Face Painting Tools
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| Nahomi OHNUKI, Yoshiaki NAKAMURA, Kiyoshi TERAJIMA, Toshiro YOKOYAMA, Shuzo OGINO and Kazuo SAITO |
| Colorants and the metals contained in transferable picture tattoos, pens and the crayons for face painting were analyzed by HPLC and X-ray fluorescence spectrometry (XRFS) analysis. Water soluble legal tar dyes, non-legal tar dyes, and oil soluble non-legal colorants were detected from picture tattoos. Non-legal oil-soluble colorants were detected from the crayons. Water-and oil-soluble legal tar dyes, non-legal colorants, and pigments were detected from the pens. The Colorant in the picture tattoos dissolved in acid artificial sweat .Copper, zinc, and manganese as the metals which possible to cause a metallic allergy were detected from the picture tattoos, pens, and crayons as a result of XRFS analysis. As there is a possibility that the infants use these picture tattoos, pens or crayons, it is necessary to investigate the safety of these products. |
| transferable picture tattoo, face/body painting, tar dye, pigments, metallic allergy, HPLC analysis, x-ray fluorescence spectrometry analysis |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,137-143,2006 |
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| 20 Improvement Simultaneous Determination of UV Absorbents in Quasi-Drugs and Cosmetics
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| Toshiro YOKOYAMA, Ken'ichiro MORI, Yoshiaki NAKAMURA, Kiyoshi TERAJIMA, Nahomi OHNUKI, Michiko MIYAMOTO, Shuzo OGINO and Kazuo SAITO |
| Improvement of the simultaneous determination of UV absorbents in quasi-drugs and cosmetics was exaninated. The chemical names and abbreviations of 13 UV absorbents are as follows: tetrahydroxybenzophenone (THB), ethyl p-aminobenzoate (EAB), dihydroxy-benzophenone (DHB), dihydroxydimethoxybenzophenone (DHDMB), 2-hydroxy-4-methoxybenzophenone (HMB), 2-ethylhexyl (Z)-4-(3,4-dimethoxybenzylidene)-2,5-dioxo-1-imidazolyzine propionate (EBP), 4-tert-butyl-4'-methoxydibenzoyl-methane (BMB), 2-ethylhexyl p-dimethylaminobenzoate (EDB), 2-ethylhexyl p-methoxy-cinnamate (EMC), 2-ethylhexyl salicylate (EHS), 2-ethylhexyl 2-cyano-3,3-diphenylacrilate (ECA), 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)-anilino]-1,3,5-triazine (TEAT), 2,2'-methylene-bis-[6-(2H-benzotriazole-2-yl)-4-(1,1,3,3-tetramethylbutyl)-phenol] (MBP). A quasi-drug or cosmetic sample of 0.4 g was weighed accurately, mixed with 4 mL of tetrahydorofurane (THF) and 6 mL of acetonitryl, dispersed by supersonic,made up to 20 mL with acetonitryl. The solution was filtered using a 0.45 µm membrane filter, and injected into HPLC. Analytical conditions of HPLC were as follows, column: ZORBAX SB-C8 (4.6 mm i.d.×150 mm), 40 °C, mobile phase: gradient, acetonitryl, water (0.2% formic acid) (40:60) to (100:0), 0.5 mL/min, injection volume 2 µL, detector UV 310 nm. By this method, 13 of UV absorbents in 10 commercial products were determined with high precision and no interference. |
| UV absorbents, quasi-drugs, cosmetics, simultaneous determination |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,145-150,2006 |
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| 21 Determination of Asbestos in Cosmetic Products by X-Ray Diffractometer
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| Yoshiaki NAKAMURA, Ken'ichiro Mori, Kiyoshi TERAJIMA, Nahomi OHNUKI, Michiko MIYAMOTO, Shuzo OGINO and Kazuo SAITO |
| Asbestos in 52 commercial cosmetics involving talc were determined by x-ray diffractometry. In 50 samples purchased from 2004 to 2005, neither tremolite nor chrysotile was detected. In 2 samples (talcum powder) purchased in 1988, both tremolite and chrysotile were detected. The content of tremolite and chrysotile was 2.0% and 4.5% in each sample, respectively. X-ray diffractometric analysis was executed according to the official method; that is, 10.5 ° diffraction angle was scanned for the confirmation of tremolite, and both 24.5 ° and 12.2 ° for chrysotile. The interference of determination with 22 coexisting ingredients in cosmetics was examined. Same mica interfered with 10.5 °, so this method was unsuitable for the determination of tremolite. Mika, chrominium oxide, red iron oxide and iron blue interfered with 24.5 °, but these four ingredients did not interfer with 12.2 ° The other 18 ingredients did not interfer at all. |
| asbestos, tremolite, chrysotile, talc, cosmetics, quasi-drugs |
| Ann.Rep.Tokyo Metr.Inst.P.H., 57,151-155,2006 |